Exosome therapeutics, a major leap forward for cell therapy.

Evora Biosciences develops exosome-based treatments, a cell-free alternative to cell therapies and the next building block for regenerative medecine.

Primary target : digestive fistula healing

Digestive fistula can be life-impairing for patients, and are linked to a variety of conditions, such as Crohn’s Disease, or surgical procedures, such as weight-loss procedures like sleeve gastrectomies.

For complex cases, currently available therapeutic options for patients and clinicians are unsatisfactory. Our lead product EVOGEX aims to dramatically improve patient outcomes in several GI-related indications.

EVOGEX stems from world class research in copolymer gels and exosomes, from CNRS and Paris University laboratories.

Exosomes : the next step in regenerative cell therapy

Exosomes are small biological particle secreted by cells, from which they carry some very interesting properties. Stem-cells derived exosomes, in particular, are able to virtually replicate the regenerative properties of their parent cells, while drastically simplifying logistics.

Compared to stem cells, exosome-based treatments offer simpler and more cost-efficient logistics, and greater ease of use for clinicians.

For patients, research has shown that exosomes have a more advantageous risk profile compared to stem cells : no donor rejection, no proliferation or differentiation risks.

The exosomes used in our treatments are produced with high-yield and scale-up compatible technologies. Compared to current-generation cell therapies, this allows for a 10x increase in production throughput in 10x less time.

Operations

Hadrien Lanvin, MSc

Founder & CEO

Amanda Silva Brun, PharmD, PhD

Founder &  CSO

Anna Kostrzak, PhD

R&D Director

Scientific Founders

Amanda Silva Brun
PharmD, PhD

2021 CNRS Innovation Medal. Galenic pharmacy and exosomes expert. Multiple patents in the field of exosomes.

Prof. Gabriel Rahmi
MD, PhD

Interventional endoscopy and digestive fistula expert.

Florence Gazeau
PhD

Nanoparticles and exosomes expert. Multiple patents in the field of exosomes.

Max Piffoux
MD-Fellow, PhD

Expert in therapeutics applications and high-yield exosomes production. Multiple patents in the field of exosomes.

Claire Wilhelm
PhD

CNRS Bronze Medal, exosomes and magnetic materials expert. Multple patents in the field of exosomes.

Partners & Ecosystem