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Evora Biosciences develops EVOGEX, a proprietary discovery platform which combine the therapeutic properties of exosomes and cell penetrating peptides.
Our off-the-shelf exosomes are engineered for improved efficacy against immuno-inflammatory diseases.
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EVOGEX is Evora’s proprietary therapeutic discovery platform, based on patent-protected peptide-engineering of exosomes.
The aim of EVOGEX is to significantly enhance key properties of exosomes, to improve efficacy of exosome-based therapeutic approaches in immuno-inflammatory diseases.
Primary target : digestive fistula healing
Digestive fistula can be life-impairing for patients, and are linked to a variety of conditions, such as Crohn’s Disease, or surgical procedures, such as weight-loss procedures like sleeve gastrectomies.
For complex cases, currently available therapeutic options for patients and clinicians are unsatisfactory. Our lead product EVOGEX-Digest aims to dramatically improve patient outcomes in several GI-related indications.
Exosomes : powerful, efficient and customizable
Exosomes are small biological particle secreted by cells, from which they inherit some key therapeutic properties. Stem-cells derived exosomes, in particular, are able to virtually replicate the regenerative properties of their parent cells, while drastically simplifying logistics.
Compared to stem cells, exosome-based treatments offer simpler and more cost-efficient logistics, and greater ease of use for clinicians.
For patients, research has shown that exosomes have a more advantageous risk profile compared to stem cells : no donor rejection, no proliferation or differentiation risks.
Lastly, exosomes are perfectly suited for engineering, which enables significant improvements of their targeting , cell penetrating and cargo delivery properties.
Operations
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Hadrien Lanvin, MSc
Founder & CEO
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Amanda Silva Brun, PharmD, PhD
Founder & CSO
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Anna Kostrzak, PhD
R&D Director
Scientific Founders
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Amanda Silva Brun
PharmD, PhD
2021 CNRS Innovation Medal. Galenic pharmacy and exosomes expert. Multiple patents in the field of exosomes.
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Prof. Gabriel Rahmi
MD, PhD
Interventional endoscopy and digestive fistula expert.
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Florence Gazeau
PhD
Nanoparticles and exosomes expert. Multiple patents in the field of exosomes.
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Max Piffoux
MD-Fellow, PhD
Expert in therapeutics applications and high-yield exosomes production. Multiple patents in the field of exosomes.
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Claire Wilhelm
PhD
CNRS Bronze Medal, exosomes and magnetic materials expert. Multple patents in the field of exosomes.
Partners & Ecosystem
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